Expression Levels of Virulence Factors with Up-regulation of Hemolytic Phospholipase C in Biofilm-forming Pseudomonas aeruginosa at a Tertiary Care Center

Pseudomonas aeruginosa is an opportunistic pathogen known to be a leading cause of nosocomial and community-acquired infections worldwide. Here, the role of biofilm formation and its possibility in enhancing the colonization and spread of P. aeruginosa in a medical center has been studied. More specifically, this study measures the in vitro production of biofilm in nosocomial and community acquired P. aeruginosa isolates representing genotypes with various prevalence rates. It also assesses the possible effect of biofilm formation on the transcription levels of virulence encoding genes.